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Depressant Effects from Cocaine: Could It Be Dangerous?

Cocaine is a powerful central nervous system stimulant drug (CNS stimulant) that may be used medically as a local anesthetic, but it is far better known for its significant abuse.

Cocaine abuse peaked in the 1980s and 1990s.

It then began to decline in the United States as other drugs of abuse, such as prescription opiates and methamphetamine became popular.

As strict controls are placed on methamphetamine and prescription drug abuse is being more tightly monitored and controlled, cocaine use has increased slightly in the United States.


Although cocaine is in the class of CNS stimulant drugs, frequently using it in large amounts can lead to feelings of depression. There are several different ways a person may experience depression resulting from their use of cocaine.

  • People who regularly use cocaine find they experience feelings of stimulation, euphoria, hyperactivity, and other effects from the stimulant effects of the drug. However, after they discontinue its use, they often find they experience a crash that consists of feelings of apathy, lack of motivation, fatigue, lethargy, increased appetite, and depressive symptoms. This cycle of ups and downs occurs most often in individuals who use large amounts of cocaine or use it on a regular basis.
  • Chronic cocaine use can lead to a person having difficulty experiencing pleasure because of the changes in neuroanatomy resulting from repeated cocaine use.
  • Excessive use of cocaine can result in the development of physical dependence (withdrawal). One of the symptoms of withdrawal from stimulants is an alteration in mood that can include feelings of depression.
  • People who buy cocaine on the street may not be getting pure cocaine. They may be getting cocaine laced with other substances that have the potential to produce feelings of depression.


Cocaine use results in the blockage of the reuptake of certain neurotransmitters in the brain. Neurotransmitters are the chemical signals that the neurons in the brain use to communicate with each other. The release of neurotransmitters in the brain accounts for a large percentage of an individual’s behavior.

Once the neurotransmitter has been released and attached to a receptor site in the brain, it performs its mission and is released into the space between neurons. A good deal of the neurotransmitter is reabsorbed back into the neuron in a process called reuptake.

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Cocaine affects numerous neurotransmitters, particularly dopamine, norepinephrine, and serotonin. When these neurotransmitters are activated, there is the perception of reinforcement or reward. Depletion of these neurotransmitters is believed to be associated with many effects, particularly depression.

These neurotransmitters are released in massive amounts when people use cocaine, and cocaine blocks their reuptake, leaving them in the space between neurons where they can reattach to the receptor sites. The high from cocaine is extremely short-lived, and abusers of the drug will often go through episodes where they binge on cocaine to maintain the feeling of euphoria.

This activity leads to a cycle of massive neurotransmitter release followed by significant decreases in their availability once a person stops using cocaine.

This cycle accounts for the crash, leads to permanent changes in the neural pathways of the brain, and results in withdrawal symptoms in those who have developed a dependence on cocaine. Over time, this can result in permanent changes in the brain that result in difficulty experiencing pleasure from events that would normally produce it. Chronic feelings of apathy or depression are more likely.


Dealers of cocaine are interested in making a profit from the drug. The cocaine that is sold on the street is rarely pure. It has often been diluted or cut significantly to produce more of the drug, thus increasing profits.

There is a long list of substances that are used to cut cocaine. Basically, any substance that is white and can be ground into a powder could be used as an additive to cocaine. These include:

  • Central nervous system depressants
  • Other stimulants
  • Hallucinogenic drugs
  • Potentially dangerous substances (chemicals, cleaners)


Many individuals who abuse cocaine use it in conjunction with other drugs that can exacerbate depressive symptoms. Most often, cocaine is abused with the following substances:

  • Alcohol
  • Other stimulants
  • Opiods
  • Sedatives like benzodiazepines

Mixing drugs with contrasting effects, like cocaine and alcohol, is a dangerous situation that can lead to serious issues with depression. Mixing cocaine with other stimulants will  exacerbate the comedown from the stimulants and can produce serious issues with depression, apathy, and a lack of motivation.


The clinical diagnosis of depression (major depressive disorder, or MDD) requires that an individual is not under the influence of any substance or that their depression is not a result of using any types of drugs or other medications.

A person who has experienced depressive symptoms as a result of cocaine use would not be diagnosed with MDD, but instead would be diagnosed with a substance- or medication-induced depressive disorder.

Symptoms of depression produced by cocaine would be expected to resolve once the effects of the drug have run their course.

Sad young woman with her head down

If the person continues to experience depressive symptoms following withdrawal from cocaine, they would be reevaluated and could be re-diagnosed.


The effects of depression can include:

  • Remain hydrated and let the episode pass
  • Get into a formal treatment program
  • Spend time with family and friends
  • Get active

Continued use of cocaine will temporarily relieve depressive symptoms; however, this is the worst way to address depression. It may lead to the development of physical dependence on the drug and a formal substance use disorder.

By definition, anyone diagnosed with any type of substance use disorder is experiencing significant distress and impairment as a result of their substance use. People who use cocaine regularly should consider receiving treatment for their substance abuse. In comprehensive treatment, individuals can address all issues related to their cocaine abuse, including depression.


(July 2018). Cocaine. National Institute on Drug Abuse. from

(November 2017), The Dangerous Hidden Ingredients in Cocaine. Verywell Mind. from

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